منابع مشابه
Platelet adhesion to surface caPtured
Type 2A Von Willebrand disease (VWD) is clinically identified by a loss of high and intermediate Von Willebrand factor (VWF) multimers resulting in a loss of platelet-dependent function. The majority of mutations that cause type 2A disease occur in the A2 domain and are grouped by their effects on cellular retention of VWF or the susceptibility of VWF to proteolysis by ADAMTS13. However, a few ...
متن کاملDifferent Stages of Platelet Adhesion to the Site of Vascular Injury
Platelet activation and adhesion to the site of vascular injury is a dynamic process comprising reversible and irreversible phases. Platelet adhesion typically occurs in a multi-step process similar to the selectin/integrin-mediated adhesion of neutrophils. This phenomenon is highly regulated and influenced by the cross-talk between platelets and injured endothelium. This cross-talk involves a ...
متن کاملPlatelet adhesion to vascular cells. The role of exogenous von Willebrand factor in platelet adhesion.
Platelet deposition on cultured fibroblasts and on their extracellular matrix (FBM) was investigated in a flow system with citrated blood and was compared with platelet deposition on cultured endothelial cells, smooth muscle cells, and their extracellular matrices. Platelet deposition was present at all surfaces except on intact endothelial cells. Deposition on FBM consisted of contact platelet...
متن کاملPrimary platelet adhesion receptors.
Thrombotic diseases such as heart attack and stroke remain a major health concern in the Western world despite existing anti-thrombotic drugs. Current studies are revealing structure-function relationships of primary platelet adhesion receptors mediating adhesion, activation and aggregation, and the molecular mechanisms underlying platelet thrombus formation. Platelet adhesion is relevant not o...
متن کاملIntegrin-mediated platelet adhesion.
Adhesion of platelets to the damaged subendothelium is a prerequisite reaction for the initiation of hemostasis in vivo. Platelet membranes contain high concentrations of integrins and other glycoproteins (GPs) that are involved in the platelet adhesion to the extracellular matrix. In the present review, we focus on two platelet integrins, integrin alphaIIb beta3 (GPIIb/IIIa) and integrin alpha...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2016-01-694935